EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

COMPARATIVE CHARACTERIZATION OF GEL LOADED OXICONAZOLE NITRATE NANOSPONGES FOR TOPICAL DELIVERY

Viresh K.C.*, Gopika S. and Shabaraya A.R.

ABSTRACT

Recent advances in nanotechnology paved path for design of nanogels with many potential applications in the field of nanomedicine. Nanogels being dispersions of hydrogel nanoparticles or nanosponges offer high drug loading compared to other nanocarriers and are thus suitable for solving issues related to stability, solubility and delayed release of actives and to formulate drug delivery systems for various administration routes besides the oral one. The objective of the present study was to formulate Oxiconazole nitrate nanosponges for topical delivery. Oxiconazole nitrate nanosponges were formulated using ethyl cellulose as polymer, polyvinyl alcohol as cross-linking agent and dichloromethane as solvent with different concentration. Which were evaluated for drug entrapment efficiency, surface morphology, particle size analysis, Zeta potential and percentage yield. Among all six different formulations F5 batch considered as the best with 88% of drug entrapment efficiency and least particle size (164.9nm). From the SEM analysis it's concluded that nanosponges are spherical, discrete with smooth surface and was loaded into the Carbopol 934 gel which were evaluated for viscosity, spreadability, pH, drug content, in- vitro drug diffusion study, release kinetics (R2 for Zero order 0.986), comparative study and stability studies. Overall, this study showed that nanosponges have a porous nature that creates a pathway for the release of the drug, and the process is simple and reproducible.

Keywords: Oxiconazole nitrate, Nanosponge, Topical gel, Ethyl cellulose, Zero order.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database