SYNTHESIS, CHARACTRIZATION AND ANTIMICROBIAL STUDIES OF CU (II) AND ZN (II) COMPLEXES WITH SCHIFF BASES
S. Anjanikar and S. Chandole*
3-acetyl 4-Hydroxy quinolin-2-one and substituted pyridine containing Schiff bases were used to synthesize Cu (II) and Zn (II) complexes. The Schiff base ligands utilised for complex formations are 4-hydroxy-3-(1-(pyridin-2-ylimino)ethyl)quinolin-2(1H)-one (L1), 4-hydroxy-3-(1-(pyridin-3-ylimino)ethyl)quinolin-2(1H)-one (L2), 4-hydroxy-3-(1-(pyridin-4-ylimino)ethyl)quinolin-2(1H)-one (L3) and 3-(1-((5-chloropyridin-2-yl)imino)ethyl)-4-hydroxy quino- lin-2(1H)-one (L4). The synthesised metal complexes were characterized by their elemental anal- ysis, magnetic moment, molar conductance along with electronic, thermal, infrared spectral analysis. Cu(II) and Zn (II) complexes of ligand (L3) were subjected for their XRD Study. On the basis of magnetic, XRD and spectral studies octahedral geometry is assigned to Cu (II) Complexes while Zn (II) Complexes possess tetrahedral geometry. In vitro biological screening effects of the synthesized complexes were tested for their antibacterial activity by Agar well diffusion method and antifungal activity by the poison plate method. For antibacterial activity the bacterial species used were Bacillus subtilis, Escherichia coli, Salmonella typhi, and Staphylococcus aureus while fungal species used were Aspergillus flavus, Penicillium chrysogenum, Aspergillus niger and Fusarium moneliforme.
Keywords: 3-acetyl 4-Hydroxy quinolin- 2-one, Schiff Bases, Metal Complexes, Spectral Analysis, XRD Studies, Antimicrobial Activity.
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