“FORMULATION AND CHARACTERIZATION OF ALMOND GUM LOADED CEFOPODOXIME PROXETIL FLOATING MICROBEADS”
S. Sarojini*, Rubashree and B. Jayanthi
The objective of the research work highlights site specific delivery of cefopodoxime proxetil in acidic PH values of stomach to improve bioavailability. Gastro retentive microbeads of Cefopodoxime proxetil by Ionotropic gelation technique was formulated in two different Combinations of sodium alginate along with almond gum and sodium alginate with HPMCE15M. The FTIR was applied to investigate drug-polymer interaction. The formulated beads were then evaluated for particle size, percentage drug entrapment efficiency, micromeritic properties, swelling property, surface topography, buoyancy properties and invitro dissolution. The best optimized formulation FC4which is more suitable for sustained release upto 12hrs, follows first order kinetics (R2 0.9537), best fitted with korsemeyer –Peppas (R2 0.9895) model showing an n value from 0.80 to 0.87 which indicate the release mechanism follows anomalous transport.
Keywords: Microbeads, almond gum, Ionotropic gelation, korsemeyer –Peppas, anomalous transport.
[Full Text Article]