INSILICO DESIGN, SYNTHESIS, AND ANTHELMINTIC ACTIVITY SCREENING OF SOME 6-BENZIMIDAZOYL PYRANS
Madhu C. Divakar* and Francis M. Saleshier
An extension of our research for novel anthelmintic agents, some hybrid derivatives containing C-2 pyran of benzimidazole were made by Michael condensation of ethyl cyano acetate in presence of pyridine. Molecular docking studies were then used to find the structural prerequisites for activity of this series of compounds. Whip worms were used in the study to screen the anthelmintic activity of the compounds synthesized. The results indicated that, all the compounds were found to be moderately effective against whip worm (Trichuris trichuria) at 1 and 2 mg/ml compared to the standard reverence drug mebendazole. The benzimidazole pyran analogue’s percentage yield obtained was found to be in the array of 55-79. The molecular docking studies revealed that, the compounds1 &3 showed good binding affinity with β-tubulin receptors.
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