EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

INTRAPERITONIAL BUPIVACAINE FOR POSTOPERATIVE ANALGESIA IN LAPAROSCOPIC CHOLECYSTECTOMY: A COMPARATIVE STUDY

Dr. Deepali Valecha*, Dr Gaurav Acharya and Dr Kk Arora

ABSTRACT

Objective: To compare the effect of intraperitoneal bupivacaine for post-operative pain management in patients undergoing laparoscopic cholecystectomy. Material and Methods: Thirty group A patients received 20 ml of 0.9% normal saline as placebo and thirty group B patients received 20 ml of 0.25% bupivacaine. All patients were pre-medicated with glycopyrrolate 0.2mg IM and ondansetron 4 mg IV half an hour prior to induction of anesthesia. All patients were given standard general anaesthesia with propofol (2-2.5 mg/kg), fentanyl 2 μg/kg, and succinylcholine (1.5 mg/kg) to facilitate tracheal intubation. Anesthesia was maintained with 50% N2O in oxygen with 2% sevoflurane. Results: The age and sex distribution of both groups were similar. The heart rate, systolic & diastolic blood pressure, mean blood pressure and mean trend of SpO2 in both groups remained similar over the periods. The mean Visual Analog Score in both groups varied considerably. It was higher in group A at 0 min, 30 minutes, 1 hour, 2 hour, 3 hour, 6 hour and 9 hour after surgery as compared to group B where, at 12 hr and 24 hrs scores were comparable. Time required for rescue analgesia was more in Group B as compared to Group A. Frequency of rescue analgesia and mean number of rescue analgesia doses were more in Group A as compared to Group B. Conclusion: We conclude that intraperitoneal instillation of local anaesthetic is an easy, cheap, and non-invasive method that provides good analgesia in the postoperative period after laparoscopic surgeries.

Keywords: Intraperitoneal Bupivacaine, laparoscopic cholecystectomy, general anaesthesia.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )