EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

ASSOCIATION OF MATERNAL SERUM VITAMIN D LEVEL WITH PREECLAMPSIA

Nigar Sultana*, Md. Hasanul Haque, Tanvir Ahmed, Mohammad Kutub Uddin, Md Mainul Islam, Zhuma Rani Paul, Maliha Parvin, Munmun Nahar Lipi and Chirangib Singha Palash

ABSTRACT

Pre-eclampsia is a pregnancy specific syndrome, often resulting in several maternal and fetal morbidities. It is a disease of theories. The main causes for this disorder have not been specifically determined so far vitamin-D deficiency is proposed to be an important element in the pathogenesis of pre-eclampsia. The aim of the study is to evaluate the association of maternal serum vitamin-D level with pre-eclampsia. A case control study carried out in the department of Obstetrics and Gynecology, Institute of Child and Mother Health (ICMH), Matuail, Dhaka, from July 2018 to June 2019. A total 60 singleton pregnant women between 18-35 years of age were included in this study in their 24-40 weeks of gestation. Among them, 30 diagnosed women with pre-eclampsia as cases and the rest of the 30 matched healthy pregnant women were selected as controls their serum vitamin-D level was measured in the laboratory of the department of Biochemistry in BSMMU, Dhaka. Proteinuria was measured by the dip-stick method. Descriptive analysis was done using the analytic software SPSS V-270, were required vitamin D deficient state was more pronounced in pre-eclamptic women than the healthy controls which was 19.1310.85 and 41.1818.61 respectively considering serum vitamin-D level of 30 as a cut-off value, odd’s ratio calculation showed pre-eclampsia incidence was 8.63 times more likely in pregnant women with vitamin-D <30ng/ml than those with <30ng/ml (OR=8.63, 95% CI=2.57-29.07). There was significant negative Pearson’s (r= -.532, p<0.001) between serum vitamin-D level with systolic blood pressure and diastolic blood pressure (r=-.460, p<0.001). The study concluded low maternal serum vitamin-D level was found strongly associated with GDM.

Keywords: .


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database