ASSOCIATION OF MATERNAL SERUM VITAMIN D LEVEL WITH PREECLAMPSIA

Nigar Sultana*, Md. Hasanul Haque, Tanvir Ahmed, Mohammad Kutub Uddin, Md Mainul Islam, Zhuma Rani Paul, Maliha Parvin, Munmun Nahar Lipi and Chirangib Singha Palash

ABSTRACT

Pre-eclampsia is a pregnancy specific syndrome, often resulting in several maternal and fetal morbidities. It is a disease of theories. The main causes for this disorder have not been specifically determined so far vitamin-D deficiency is proposed to be an important element in the pathogenesis of pre-eclampsia. The aim of the study is to evaluate the association of maternal serum vitamin-D level with pre-eclampsia. A case control study carried out in the department of Obstetrics and Gynecology, Institute of Child and Mother Health (ICMH), Matuail, Dhaka, from July 2018 to June 2019. A total 60 singleton pregnant women between 18-35 years of age were included in this study in their 24-40 weeks of gestation. Among them, 30 diagnosed women with pre-eclampsia as cases and the rest of the 30 matched healthy pregnant women were selected as controls their serum vitamin-D level was measured in the laboratory of the department of Biochemistry in BSMMU, Dhaka. Proteinuria was measured by the dip-stick method. Descriptive analysis was done using the analytic software SPSS V-270, were required vitamin D deficient state was more pronounced in pre-eclamptic women than the healthy controls which was 19.1310.85 and 41.1818.61 respectively considering serum vitamin-D level of 30 as a cut-off value, odd’s ratio calculation showed pre-eclampsia incidence was 8.63 times more likely in pregnant women with vitamin-D <30ng/ml than those with <30ng/ml (OR=8.63, 95% CI=2.57-29.07). There was significant negative Pearson’s (r= -.532, p<0.001) between serum vitamin-D level with systolic blood pressure and diastolic blood pressure (r=-.460, p<0.001). The study concluded low maternal serum vitamin-D level was found strongly associated with GDM.

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