PREPARATION AND EVALUATION OF PIOGLITAZONE SOLID DISPERSIONS

Venkatesh*, Anand Kumar Y. and C. Mallikarjuna Setty

ABSTRACT

Pioglitazone HCl (PIO) is a poorly soluble bioactive compound that suffered bioavailability problems after oral administration. Hence, the aim of the proposed research work was to formulate and investigate various solid dispersions (SDs) of PIO in order to enhance its dissolution and bioactivity. PIO-SD were prepared using poloxamer and HPMC at 1:1 and 1:3 ratios by kneading and microwave irradiation methods. The prepared PIO-SD characterized by differential scanning calorimetry (DSC), FTIR and evaluated for in vitro dissolution. The results of FTIR and DSC suggest the formation of PIO-SD. The superior solubility and dissolution properties of PIO-SD over pure PIO and justified by statistically at 95 % confidence through ANOVA. Therefore the SD prepared with poloxamer and HPMC could be a potential technique for enhancing the solubility and in vitro dissolution.

Keywords: Solid dispersion systems, Pioglitazone HCl, HPMC, Poloxamer-407, FTIR, DSC.