EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

EFFECTS OF NATURAL COMPOUNDS AS TOPICAL MELANOLYTIC AGENTS AND THEIR MECHANISM FOR THE TREATMENT OF HYPERPIGMENTATION

Gulafsha Kassab, Tasneem Husain and Sharique A. Ali*

ABSTRACT

Skin lightening products are available in the market for aesthetic purposes, and also for the treatment of depigmentation disorders, such as melasma and post-inflammatory hyperpigmentation. They work with multiple stages of melanin synthesis in the skin such as tyrosinase inhibitors, which have been the main enzymes associated in melanogenesis. Melanin is a pigment that determines skin colour and other phenotypic characteristics which also helps to protect the skin from UV radiation. But its excess production and distribution leads to hyperpigmentation and its related disorders. Several treatment strategies have been used to treat abnormal melanin or hyperpigmentation, including chemical peeling, dermabrasion, laser, topical treatment, etc. But skin burn, dyspigmentation, acne, swelling, pain etc. are some of the after-effects found associated with these treatment options. Hence there is a need to develop natural depigmenting agents for the treatment of abnormal skin pigmentation or depigmentation without any side effects. In the present review, we have discussed some of these plants and their active ingredients which have been successfully used for the treatment of hyperpigmentation. It provides an overview of natural whitening agents for the treatment of diminished skin pigmentation by interfering with pigmentary processes.

Keywords: Melanin, hyperpigmentation, Pigmentation, Whitening agents.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia