CO-CRYSTAL TECHNIQUE OF SOLUBILITY ENHANCEMENT COMPREHENSIVE REVIEW
Mayuri Kondapalli*, Shravasti Banoth, Sai Priya Bairagoni and Hyma P.
ABSTRACT
Co-crystal is a unique crystalline material containing two molecular components solid at room temperature having defined stoichiometric ratio. For administration of high doses of drugs such as HIV/AIDS, tuberculosis and other cocrystal are drug combination strategies used for the treatment and management of drug resistance and adverse reactions Improving the various parameters of a drug molecule such as solubility, melting point, pharmacokinetic, pharmacodynamic and bioavailability is possible through co-crystals. Various validation instruments such as x-ray diffraction and differential scanning calorimetry gives the overview of qualitative and quantitative aspects of co-crystals and evaluation of co-crystals. Attention of co-crystals in the discovery plays a role in drug design and development. A complete case study of theophylline and 5-nitrouracil regarding co-crystal. methodology and overview and methods of preparation of co-crystal.
Keywords: Pharmaceutical Co-Crystal, Conformer, 5-Nitrouracil, Theophylline, Physicochemical properties.
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