EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

FORMULATION AND CHARACTERIZATION OF TOPICAL LYCOPENE PHYTOSOMES FOR IMPROVED PERMEATION

Viresh K. Chandur* and Ramkrishna Shabaraya A.

ABSTRACT

Objective: An attempt was made to develop topical delivery of lycopene for its beneficial use as an anti-oxidant by phytosome technology. Material & Method: Phytosomes were prepared by refluxing or dissolving different ratios of lycopene in chloroform or hexane and Phospholipid in dichloromethane involved precipitation sonication method. 1% equivalent complex was placed in three different formulations of Cream and hydrophilic gel bases made out of steric acid and Carbopol respectively for better utility. Formulations were evaluated for appearance, pH, viscosity, Spreadability, Extrudability, washable property and in vitro diffusion to check for its stability. Results & Discussion: 1: 1 molar ratio was found to be the best phytosomal complex with entrapment efficiency of 83.22±0.54 % and physicochemical parameters showed acceptable results for both creams and gels for pH in range of 6.4±0.043 to 6.95±0.041 compatible to skin pH with less irritation. Viscosity 3.28±44.04 kP for cream and Gel 5.8±56.88 kP, Spreadability 14.66±0.04 g*cm/sec for cream and gel 36.22±0.04 g*cm/sec and % decrease Extrudability for cream 99.17±0.05 and gel 99.84±0.04 respectively showed inter related parametric performance for better results. In- vitro studies were found to be fare release up to 95% for creams and gels at the end of 5 h. Stability studies was carried out at two different temperature at 30 o C ±0.5oC and 65% RH±2 RH and 4 o C ±0.5oC and 75%RH for 90 days and found to be stable.

Keywords: Lycopene, Phytosomes, Spreadability, Extrudability, Skin irritation.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia