EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

FORMULATION DEVELOPMENT AND EVALUATION OF ANTIDIABETIC ACTIVITY OF AEGLE MARMELOS ROOTS (RUTACEAE)

Chaturvedi Abhishek*, Tiwari Dilip Kumar, Mehta Parul Ben D.

ABSTRACT

Diabetes mellitus (DM) is one of the leading metabolic disorders worldwide. Diabetes mellitus is due to a lack of function of β pancreatic cells or insensitivity of target tissue to insulin. This disorder not only affects the metabolic system but also causes various associated problems like neuropathy, nephropathy, retinopathy, and heart-related disease. Treatment of Diabetes mellitus (DM) with allopathic drugs for a long duration has been not safer and may cause several adverse effects along with hypoglycemia. World health organization (WHO) recommended drug researchers emphasize herbal-based research which is safer and more effective for longer regimens in dosing. Hence this work is attempted to exploit natural resources, abundantly available in our surroundings and also evident in the traditional system of medicine. In this research work Aegle marmolus roots extract were exploited for anti-diabetic potential by in-vitro method. Result were shown α-amylase inhibitory activities IC50 112 μg/ml. EEAMR exhibited highest percentage of glucose uptake i.e. 54.84±0.752, which was almost near to the standard i.e. 61.74±0.527.

Keywords: Diabetes mellitus, Hypoglycemia, Neuropathy, Retinopathy, ?-amylase, Aegle marmolus.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database