FORMULATION DEVELOPMENT AND EVALUATION OF ANTIDIABETIC ACTIVITY OF AEGLE MARMELOS ROOTS (RUTACEAE)
Chaturvedi Abhishek*, Tiwari Dilip Kumar, Mehta Parul Ben D.
Diabetes mellitus (DM) is one of the leading metabolic disorders worldwide. Diabetes mellitus is due to a lack of function of β pancreatic cells or insensitivity of target tissue to insulin. This disorder not only affects the metabolic system but also causes various associated problems like neuropathy, nephropathy, retinopathy, and heart-related disease. Treatment of Diabetes mellitus (DM) with allopathic drugs for a long duration has been not safer and may cause several adverse effects along with hypoglycemia. World health organization (WHO) recommended drug researchers emphasize herbal-based research which is safer and more effective for longer regimens in dosing. Hence this work is attempted to exploit natural resources, abundantly available in our surroundings and also evident in the traditional system of medicine. In this research work Aegle marmolus roots extract were exploited for anti-diabetic potential by in-vitro method. Result were shown α-amylase inhibitory activities IC50 112 μg/ml. EEAMR exhibited highest percentage of glucose uptake i.e. 54.84±0.752, which was almost near to the standard i.e. 61.74±0.527.
Keywords: Diabetes mellitus, Hypoglycemia, Neuropathy, Retinopathy, ?-amylase, Aegle marmolus.
[Full Text Article]