DESIGN, SYNTHESIS AND ANTIMICROBIAL EVALUATION OF SCHIFF BASE 4- THIAZOLIDINONES FOR PHARMACEUTICALS

*Anurudh Kumar Verma, Dr. Amit Kumar Nigam and Dr. Amresh Gupta

ABSTRACT

Illness has been a part of man's history since the dawn of time, and the hunt for cures is possibly as old. Kidneys & liver are major organs valued for medication removal from body. This study was based on to synthesize novel Schiff bases by combining 4-aminosalicylic acid with diverse 2-chloro, 2-hydroxy, and 2-thio-3-formylquinolines. In thioglycolic acid and anhydrous Zinc chloride, all Schiff bases will be transformed into thiazolidinones. Using a conventional approach, all such compounds are tested for their antibacterial potential against diverse strains. Antibacterial and antifungal properties were tested on all produced substances. In tests, substances showed high potency to moderate antibacterial activity against S. pyogenus (Gm-ve) and E. coli bacteria. These compounds were found microbes sensitive but not fungus. It suggests to test their antibacterial potential in vivo using animals then human beings. A significant data in preclinical and clinical trials will prove their use in clinical settings.

Keywords: Synthesis, antimicrobial, Schiff base 4-thiazolidinones, E. coli.