EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

GENETIC & MOLECULAR BASIS OF PRIMARY OPEN ANGLE GLAUCOMA (POAG) PATHOGENESIS

Faisal Ahmad Lone, Ayaz Mahmood Dar*, Musharaf Rehman and Mukesh Kumar

ABSTRACT

Herein we compile the different studies regarding the cause of primary open angle glaucoma (POAG). The apoptotic theory of glaucoma suggests that ganglion cells contain protein receptors that, when activated by glutamate, increase intracellular calcium to toxic levels, forming destructive free radicals (ROS) that kill the cells. Neurotrophic nutrient deprivation theory reveals that the deprivation of vital neurotrophic nutrients for the retinal ganglion cells from the lateral geniculate nucleus. We herein also report some of the studies involving structural changes which occur in N-terminal of the myocillin involved extensive insertions and deletions while the C-terminal region involved point mutations, which may also lead to POAG. We also report herein the molecular biological studies, which suggest that mutant protein could be present through heteroaggregates in the aqueous humor (AH) and uveoscleral AH outflow of glaucoma patients that play an important role in the glaucoma pathogenesis. Another study was considered here about the endoplasmic stress that reveals that myocilin-associated POAG can be considered as an ER storage disease, occurring in steps that involves expression of misfolded and non-secreted myocilin, subsequent TM cell death. From the above evidences it might be intriguing to evaluate whether myocillin mediated ER stress induces autophagy in TM cells.

Keywords: POAG, Glaucoma, Myocillin, Mutations, Locus, ER stress.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia