EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

ANTI-CARCINOGENIC POTENTIAL OF BIOCHANIN-A: AN OVERVIEW

*Gupta Ritesh Vinod and Shalini Singh

ABSTRACT

Phytoestrogens are substances that are present in plants that have an estrogen-like molecular structure and size. An isoflavone called biochanin A (also known as 5,7-dihydroxy-4'-methoxy-isoflavone, or BCA) is found in red clover, cabbage, alfalfa, and many other herbal items. It is a naturally found isoflavone found in several clover species' legumes, most notably red clover, as well as in numerous herbal nutritional supplements. Numerous research looking at the therapy of cancer have explored BCA. In 1988, a hamster embryo cell culture experiment was conducted, and it shown that BCA prevented carcinogen activation. Some kinds of cancer have been shown to occur less frequently when COX-2 is inhibited. BCA protects against oxidative stress and prevents invasive enzyme production and activity. The most significant finding was that, at the moderate concentration at which it suppressed cancer cells, BCA had no such effects on healthy tissues or cells. BCA is regarded as a powerful cancer-fighting chemo preventive and/or therapeutic agent. Overall, Biochanin-A appears to provide a dual targeted agent that inhibits two processes, invasion, and angiogenesis. The target genes' transcription is then stimulated by the translocation of the freed NF-B dimmers into the nucleus. In concluded that BCA has anti-cancer potential when studied in different cancer types. It might be recommended in the treatment of carcinoma as a part of chemotherapy.

Keywords: Biochanin-A, review, COX-2, anti-carcinogenic, colon cancer.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database