ANTI-CARCINOGENIC POTENTIAL OF BIOCHANIN-A: AN OVERVIEW
*Gupta Ritesh Vinod and Shalini Singh
Phytoestrogens are substances that are present in plants that have an estrogen-like molecular structure and size. An isoflavone called biochanin A (also known as 5,7-dihydroxy-4'-methoxy-isoflavone, or BCA) is found in red clover, cabbage, alfalfa, and many other herbal items. It is a naturally found isoflavone found in several clover species' legumes, most notably red clover, as well as in numerous herbal nutritional supplements. Numerous research looking at the therapy of cancer have explored BCA. In 1988, a hamster embryo cell culture experiment was conducted, and it shown that BCA prevented carcinogen activation. Some kinds of cancer have been shown to occur less frequently when COX-2 is inhibited. BCA protects against oxidative stress and prevents invasive enzyme production and activity. The most significant finding was that, at the moderate concentration at which it suppressed cancer cells, BCA had no such effects on healthy tissues or cells. BCA is regarded as a powerful cancer-fighting chemo preventive and/or therapeutic agent. Overall, Biochanin-A appears to provide a dual targeted agent that inhibits two processes, invasion, and angiogenesis. The target genes' transcription is then stimulated by the translocation of the freed NF-B dimmers into the nucleus. In concluded that BCA has anti-cancer potential when studied in different cancer types. It might be recommended in the treatment of carcinoma as a part of chemotherapy.
Keywords: Biochanin-A, review, COX-2, anti-carcinogenic, colon cancer.
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