SOLID-LIPID NANOPARTICLES FOR THE TREATMENT OF CANCER

Aparna Dwivedi*, Arti Singh and Shipra Tripathi

ABSTRACT

The SLNs (Solid-Lipid nanoparticles) technology is one of the most promising drug carriers for bioactive chemical molecules. By enhancing a range of chemotherapeutics' anticancer effects, its current use in chemotherapy has changed how cancer is treated. It has excellent temporal and thermal stability, cheap preparation method and high manufacturing yield as they may be made from naturally existing sources. Additionally, mixing chemotherapeutic agents with LNPs reduces therapy resistance, decreases toxicities, increases drug concentration in cancer cells while decreasing concentrations in healthy tissue. Both in vitro and in vivo studies on SLNs for the treatment of cancer were extensive, with positive results in several clinical trials. The current paper gives a broad summary of the various SLN kinds that have been developed recently, as well as their uses and contributions to various malignancies.

Keywords: Solid-Lipid nanoparticles, cancer, tumor, drug delivery system.