MEASUREMENT OF SERUM CALCIUM, PHOSPHATE AND PARATHORMONE LEV-ELS IN THALASSEMIC CHILDREN

Dr. Md. Al Mamun Hossain*, Dr. Pandora Glory, Dr. Md. Shafiqul Islam, Dr. Syeda Nazmatul Hasnat, Dr. Sakina Shab Afroz, Dr. Farzina Islam

ABSTRACT

Background: Chronic haemolytic anemia most often results from thalassemia. The symptoms of thalassemia, which include severe anemia needing frequent RCC transfusions, often manifest during the first two years of life. Even while modern transfusion techniques have enhanced thalassemia patients' life expectancy, they have also led to growing iron overload. These patients have endocrine disruption due to iron excess. Objective: To measure the level of serum calcium, phosphate and parathormone levels among thalassemic children. Method: This cross sec-tional study was carried out at tertiary hospital from January 2021 to January 2022 where a total of 100 children with thalassemia from 4 years to 14 years that requiring frequent blood transfusion and attending Outpatient and In-Patient Department were included as a sample size. Results: During the study, majority belong to 5-10 years age group, 65% and 55% were male. 75% had annual packed cell requirement rate was 120 and 16% had annual cell requirement rate was 240. Majority had higher serum ferritin level, 70% whereas 45% had 8.19mg/dl calcium level followed by 30% had 7.1-8mg/dl calcium level, 15% had >9mg/dl. majority belong to <5mg/dl serum phos-phorus level, 45%. Followed by 25% belong to 5-5.9 mg/dl serum phosphorus level, 26% belong to 6-6.9mg/dl. Moreover, according to serum parathormone level in Thalassemia Patient 96% cases belong to 12-65 pg/ml. Con-clusion: Hypoparathyroidism is more common in those with thalassemia. 10% patients in our research had an in-adequate amount of parathormone. There is a considerably higher frequency of hypoparathyroidism in children with thalassemia between the ages of 11 and 14 than in those between the ages of 5 and 10. Therefore, after the age of 10, it is crucial to actively look for hypoparathyroidism so that therapy may begin without delay.

Keywords: Thalassemia, serum ferritin, serum calcium, serum phosphorus.