EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

MEASUREMENT OF SERUM CALCIUM, PHOSPHATE AND PARATHORMONE LEV-ELS IN THALASSEMIC CHILDREN

Dr. Md. Al Mamun Hossain*, Dr. Pandora Glory, Dr. Md. Shafiqul Islam, Dr. Syeda Nazmatul Hasnat, Dr. Sakina Shab Afroz, Dr. Farzina Islam

ABSTRACT

Background: Chronic haemolytic anemia most often results from thalassemia. The symptoms of thalassemia, which include severe anemia needing frequent RCC transfusions, often manifest during the first two years of life. Even while modern transfusion techniques have enhanced thalassemia patients' life expectancy, they have also led to growing iron overload. These patients have endocrine disruption due to iron excess. Objective: To measure the level of serum calcium, phosphate and parathormone levels among thalassemic children. Method: This cross sec-tional study was carried out at tertiary hospital from January 2021 to January 2022 where a total of 100 children with thalassemia from 4 years to 14 years that requiring frequent blood transfusion and attending Outpatient and In-Patient Department were included as a sample size. Results: During the study, majority belong to 5-10 years age group, 65% and 55% were male. 75% had annual packed cell requirement rate was 120 and 16% had annual cell requirement rate was 240. Majority had higher serum ferritin level, 70% whereas 45% had 8.19mg/dl calcium level followed by 30% had 7.1-8mg/dl calcium level, 15% had >9mg/dl. majority belong to <5mg/dl serum phos-phorus level, 45%. Followed by 25% belong to 5-5.9 mg/dl serum phosphorus level, 26% belong to 6-6.9mg/dl. Moreover, according to serum parathormone level in Thalassemia Patient 96% cases belong to 12-65 pg/ml. Con-clusion: Hypoparathyroidism is more common in those with thalassemia. 10% patients in our research had an in-adequate amount of parathormone. There is a considerably higher frequency of hypoparathyroidism in children with thalassemia between the ages of 11 and 14 than in those between the ages of 5 and 10. Therefore, after the age of 10, it is crucial to actively look for hypoparathyroidism so that therapy may begin without delay.

Keywords: Thalassemia, serum ferritin, serum calcium, serum phosphorus.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database