EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

ADVERSE EFFECTS OF BENZENE EXPOSURE ON HEMATOLOGICAL AND HEPATIC BIOCHEMICAL PARAMETERS OF PETROL FILLING WORKERS IN WADI AL-HAYAH, LIBYA

Apoajela A. Ahmed*, Waled Alsalmi, Aboubaker A. Elhadi and Monder M. Almarabet

ABSTRACT

Benzene exposure is known to affect many critical organs including the hematological and hepatic functions promoting various and dangerous health problems. The primary objective of the study was to evaluate the hematological and hepatic function profiles among petrol filling workers in petrol stations located in Wadialhayah, southwest Libya. Second objective was to investigate the extent changes of hematological and hepatic biochemical parameters in accordance to the period of benzene exposure. A total of 92 adult male subjects whose ages ranged between 20-45 years were included in this study, 46 of petrol filling workers (benzene exposed group) and 46 subjects (benzene unexposed group) as a control group. Both groups were matched in ages and gender. All the results were statistically analyzed using SPSS version 20 for applying one way ANOVA test. The mean age of petrol filling workers (benzene exposed group) and non exposed group were 34.36 7.26 and 33.80 7.02 years, respectively. Length of work duration for exposed group was 7.50 1.56 years. Significant decrease in the levels of RBCs, Hb, HCT, MCH, total protein and serum albumin among benzene exposed group as compared to unexposed group while MCV levels were almost the same and were not significant for both groups. On the other hand, WBCs, platelets, SGPT and SGOT levels were significantly increased among benzene exposed group as compared to unexposed group. Moreover, significant changes of hematological and hepatic biochemical parameters caused by prolonged benzene exposure. It is concluded that benzene exposure has serious health effects on hematopoietic system and hepatic functions leading to suppressed bone marrow. Moreover, long term benzene exposure causes more alterations in hematological and hepatic parameters.

Keywords: hematological parameters, hepatic parameters, benzene exposure and petrol stations.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database