EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

ADMINISTRATION OF A FORMULATED HERBAL MIXTURE (DIB) CAUSED A SIGNIFICANT INCREASE IN CD4 COUNTS AND REDUCTION IN HIV RNA OF VOLUNTEERED HIV PATIENTS ON ANTIRETROVIRAL THERAPY

Bamikole A. Ojo.*, Tinuola T. Adebolu., Ayodele O. Ogundare, Babayemi O. Oladejo and Adeleye T.E.

ABSTRACT

The scourge of HIV infection is yet to be brought under control. One major reason for this is the problem of resistance of the virus to available antiretroviral drugs. Another reason is the lack of access to these drugs in most rural communities where conventional treatment is non-existent. Therefore, the need for complementary and /or alternative treatments. In this study, a formulated herbal mixture (DIB) made from Sorghum bicolor L., Curcuma longa L., Bridelia ferruginea B. and honey was assessed as a complementary therapy for the management of HIV-positive individuals on antiretroviral therapy (ART). A total of 16 HIV-positive individuals attending a government-approved ART clinic in Nigeria who indicated interest in the investigation were recruited for this study. The volunteers were divided into two groups: A (12; administered DIB) and B (4; not administered DIB). The CD4 counts and the viral loads of these patients were assessed before the commencement of the administration of DIB and follow-up CD4 counts and viral load assay were carried out at the 3rd month and 6th month of continuous administration of DIB for Group A patients. The CD4 counts and the viral loads of group B patients which served as control were also assessed simultaneously. There was a progressive increase in the CD4 counts from the baseline (i.e., prior administration of DIB to the patients) to the sixth month of the administration of DIB to group A patients as compared to those in group B that were not administered DIB and there was reduction in viral load to an undetectable level (TND) in HIV patients administered DIB compared to patients not administered DIB who still recorded detectable HIV RNA at 6th month of the study. Thus, the progressive increase in CD4 count and the no detection of HIV RNA among patients administered DIB continuously for 6 months show the promise of DIB as a complementary therapy in the management of HIV patients. Therefore, DIB might be an option to consider as a complementary therapy in the management of HIV patients.

Keywords: Herbal product, HIV, Viral load, CD4 count, Target-not-detected, Complementary therapy.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia