MALNUTRITION, INFLAMMATION AND ATHEROSCLEROSIS COMPONENTS IN ENDSTAGE RENAL DISEASE PATIENTS UNDERGOING HEMODIALYSIS OR PERITONEAL DIALYSIS

Raji R.P. and M.K. Mohan Das*

ABSTRACT

Introduction: Malnutrition, inflammation and atherosclerosis are associated with significant morbidity and morality in ESRD patients undergoing renal replacement therepy. In this study we tried to find out the prevalence of malnutrition, atherosclerosis and inflammation in ESRD patients undergoing hemodialysis or peritoneal dialysis. We also studied factors influencing the development of malnutrition, inflammation and atherosclerosis. The prevalence of malnutrition, inflammation and atherosclerosis was compared between the two dialysis modalities. Methods: Total 150 dialysis patients were studied (114 HD patients and 36 CAPD patients). Malnutrition was assessed by BMI. Serum albumin and cholesterol. Inflammation was assessed with CRP. Atherosclerosis was assessed with carotid intima media thickness using B mode ultrasound. Findings: Out of 150 patients in our studying population74.67 % patients had malnutrition, 62 % had inflammation and 74.67 % had atheroscrierosis. Among patients who are undergoing hem dialysis 72.8 % had malnutrition. Where as 80.56 % of CAPD patients had malnutrition. Inflammation was see in 66.67 % of patients undergoing HD and 47.22 % of patients undergoing CAPD and the difference was statistically significant. Atherosclerosis was seen in 78.07% of patients undergoing HD and 63.89 % of patients undergoing CAPD. There was no statistically significant difference in the prevalence of malnutrition and atherosclerosis between HD and CAPD patients. Discussion: Prevalence of malnutrition, inflammation and atherosclerosis is significantly high in ESRD patients undergoing renal replacement therapy.

Keywords: Malnutrition, atherosclerosis, inflammation, ESRD.