EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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Abstract

DEVELOPMENT AND VALIDATION OF UV SPECTROSCOPIC METHOD FOR THE QUANTIFICATION OF MEBEVERINE HYDROCHLORIDE IN BULK AND MARKETED TABLETS

Aayush Nahar, Yegnoor Anand Kumar*, Neeladri Srinivasulu, Syed Hafeez Pasha Qhadri and Avanish Srivastav

ABSTRACT

Two Simple and precise UV spectroscopic methods were developed and validated as per ICH guidelines. The solvent systems such as Acetonitrile: Methanol (1:1) and Distilled water: Methanol (2:1) selected for the study. The two proposed solvent systems validated for linearity, accuracy, precision, robustness, ruggedness and solution stability. The percent recovery in the marketed tablet formulation was found to be good agreement with the label claim. The proposed methods validated statistically and the results suggest these methods can employ for the routine analysis of mebeverine hydrochloride in bulk and marketed formulations.

Keywords: Mebeverine hydrochloride, UV spectroscopy, Validation, Accuracy, Precision.


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SJIF Impact Factor: 7.065

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