DESIGN AND CHARACTERIZATION OF EMULGEL OF AN ANTIMICROBIAL DRUG METRONIDAZOLE

Vaishnav R. Thazhapurayil*, Sulbha G. Patil, Amruta N. Patil, Sandip A. Tadvi, Nishant M. Patel, Vaishnavi J. Patil

ABSTRACT

Emulgel is one of the emerging topical drug delivery system for the delivery of hydrophobic drugs which overcome various disadvantages of ointments and creams such as greasiness and phase inversion. The aim of present work was to develop and evaluate Metronidazole emulgel with controlled release. The Metronidazole used in treatment of various bacterial and fungal infections such as cutaneous and subcutaneous diseases like acne and psoriasis. Different formulations (F1-F4) of Metronidazole emulgel was prepared by using sodium alginate with varying concentrations as gelling agent with oil phase such as mentha oil and Tween-20 and Span-20 as a emulsifying agent. The prepared emulgels were evaluated for physical appearance, pH, drug content, In-vitro diffusion studies. By the In-vitro diffusion studies it was observed that formulation F4 showed 93.20% of drug release after 6 hours and results concluded that the formulation F4 showed better releasing of drug.

Keywords: Topical delivery, Antimicrobial agent, Emulgel.