( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57



Pratheesh Xavier P.*, Melwinraj A., Naveena B., Narmatha M. and Thirupathy Kumaresan P.


Chronic obstructive pulmonary disease is a progressive inflammatory disease of the lung characterized by chronic bronchitis, airway thickening and emphysema. Pulmonary inflammation is prominent in chronic obstructive pulmonary disease and corticosteroids are generally used in controlling the inflammation. The inflammation in chronic obstructive pulmonary disease is dominated by neutrophilic infiltration, with an increased numbers of macrophages and CD8 T lymphocytes; neutrophilic infiltration is not as responsive to steroids as the eosinophilic inflammation seen in asthma. Current guidelines highlight the fact that for chronic obstructive pulmonary disease patients uncontrolled by bronchodilator monotherapy, the use of a combination therapy is recommended. The combination of long acting beta agonists and inhaled corticosteroids is the most common in use for both chronic obstructive pulmonary disease and asthma. Inhaled corticosteroids and long acting beta agonists combination products have been shown to improve lung function, symptoms, and health status, and they reduce exacerbations in patients with moderate to severe chronic obstructive pulmonary disease . A more recently published retrospective analysis of veterans treated with tiotropium revealed that inhaled corticosteroids and long acting beta agonists and long acting muscarinic antagonists therapy was associated with a 40% reduction in mortality compared with treatment with inhaled corticosteroids plus long acting beta agonists. The adverse effects from the use of inhaled corticosteroids in patients with Chronic obstructive pulmonary disease, most notably severe pneumonia results in excess deaths.

Keywords: Glucocorticoid receptor; Nuclear factor-?B; Inflammatory gene; Histone deacetylase; Eosinophil, Epithelial cell; Inhaled corticosteroids; Inflammation; Pneumonia.

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  • New Issue Published

    Its Our pleasure to inform you that, EJPMR 1 May 2024 Issue has been Published, Kindly check it on


    MAY 2024 issue has been successfully launched on MAY 2024.

  • EJPMR New Impact Factor

    EJPMR Impact Factor has been Increased to 7.065 for Year 2024.

  • Index Copernicus Value

    EJPMR Received Index Copernicus Value 79.57, due to High Quality Publication in EJPMR at International Level

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia