A REVIEW ON ADVANCES OF LIPOSOMES AS DRUG DELIVERY

Bhavin D. Pandya*, Shreyash A. Diwakar and Ajay K. Saluja

ABSTRACT

Liposomes are spherical vesicles composed of one or more concentric phospholipid bilayers, surrounding an aqueous core that can be loaded with drugs. Liposomes represent a powerful new drug delivery system for entrapping both hydrophilic and hydrophobic drugs as non-toxic and biodegradable formulations. Overcame tissue uptake and increased biodistribution of the drug to target sites in vivo while minimizing systemic toxicity. This review provides a complete overview of liposome composition, properties, types, advantages, disadvantages, manufacturing processes, drug loading, characterization, applications and commercially available liposomal formulations.

Keywords: Liposomes, Targeted drug delivery, Characterization, Applications, Marketed liposomes.