CLINICAL PERSPECTIVES OF GLYCEMIC VARIABILITY AND UNDERSTANDING ITS ROLE TOWARDS CONTRIBUTION OF GLYCEMIC CONTROL IN DIABETIC PATIENTS

Kowsalya Devi S.*, Medona Judith M., Kishore Pandi M. and Santhanakumar M.

ABSTRACT

Diabetes mellitus word is came from the Greek phrase diabetes, that means siphon - to pass through and the Latin word mellitus which means sweet. A review of the history records indicates and shows that the term "diabetes" was first used by Apollonius of Memphis around 250 to 300 BC. Diabetes mellitus (DM) is a metabolic disease, involving inappropriately elevated blood glucose levels. Hemoglobin A1c (HbA1c) is the most extensively used parameter for glycemic monitoring and throw back average glucose levels over 2–3 months. Published research studies have confirmed that GV, especially when related with extreme hypoglycemia, could be harmful not only to people with diabetes but also to non-diabetic patients in critical care settings. The attention dedicated to GV is derived from the above proof regarding concerning its effects on oxidative stress and, from the latter, on chronic diabetes complications. Control of GV has been the focus of a number of interventional studies aimed at reducing this fluctuation. Diet and weight lowering are the first and initial therapeutic instrument that can be used for decreasing GV. The current article reviews the clinical perspectives of GV and understanding its role toward contribution of glycemic control in diabetic patients.

Keywords: Glycemic Variability, HbA1c, Diabetes mellitus.