A REVIEW ON MUCOADHESIVE BILAYER BUCCAL DRUG DELIVERY: A PROMISING APPROACH

Mohammed Omer* and S. M. Shahidulla

ABSTRACT

The traditional and most common method of drug administration is the per oral administration of drugs but in these case drugs bioavailability is reduced as it is subjected to extensive pre-systemic degradation in the gut wall (or) liver. One of the non-invasive routes known as Buccal route drug delivery which comprises of several advantages such as targeting the specific tissue bypassing the first-pass effect, as well as higher patient compliance and higher bioavailability and have rendered administration route feasible for a variety of drugs. Mucoadhesive delivery is a dosage form which is designed to enable prolonged retention at the site of application, providing a controlled rate of drug release for improved therapeutic outcome and the use of mucoadhesive materials which act as hydrophilic macromolecules containing numerous hydrogen bond forming groups helps in the process. The medicines which consist of one or different drugs combined in a single dose for effective treatment of the disease are generally defined by the term Bilayer tablets.

Keywords: Buccal mucosa, Mucoadhesion, Bilayer tablet, Buccal delivery system.