NANOEMULGEL – AN INNOVATIVE APPROACH FOR TOPICAL DELIVERY USING HIGH ENERGY METHOD

Dr. Abdul Mannan, Arkaan Qamar Abbas, Uzma Amatul Aleem*

ABSTRACT

As an emerging transdermal delivery tool, nanoemulgel, has proved to show astonishing upshots for the lipophilic drugs over other formulations. The goal of this review is to formulate the nanoemulsion using microfluidizer to achieve better stability of formulations and to evaluate and report the current potential and future scope of nanoemulgel formulation for becoming an effective delivery system for poorly water-soluble drugs. Lipophilic drugs can be easily incorporated and the skin permeability of the incorporated drugs can be increased in several folds due to the finely distributed oil droplets in gel phase. Concurrently, it can be targeted more specifically to the site of action and can avoid first pass metabolism and aid the user from gastric/systemic incompatibilities. The nanoemulgel drug delivery system is a formulation related intervention to enhance drug absorption and therapeutic profile of lipophilic drugs. An emerging trend has been noticed in recent years in the use of nanoemulgel due to the better acceptability of the formulation to the patients due to their non-greasy nature which favours user compliance, convenience, spreadability, and easy applicability and good therapeutic and safety profile. Despite having few drawbacks, nanoemulgel formulation can be considered as potential and promising candidates for topical delivery of lipophilic drugs in the future.

Keywords: Nanoemulgel; Nano emulsion; Topical drug delivery; High Energy Method.