EVALUATION OF ANTIDIABETIC EFFECTS OF CARISSA OPACA LEAVES EXTRACTS AGAINST ALLOXAN INDUCED DIABETES IN RATS
Jainedra Kumar*, Shamim Ahmad, Sudha, Shaily Mishra and Huma Khan
Diabetes mellitus is heterogeneous metabolic disorder characterized by disturbances of carbohydrate, fat, protein metabolism. It is often connected with the development of micro and macro vascular diseases which include a long-term damage dysfunction and failure of various organs especially the eye, nerves, heart, kidney, and blood vessels. There are approximately 20.8 million people in the United States or 7% of the population, who have diabetes. Of those, 14.6 million people have been diagnosed but an estimated 6.2 million people are unaware that they have the disease. In addition to those people with diabetes, there are an additional 41 million Americans who are pre-diabetic. Data from death certificates indicate that diabetes contributed to 224,092 deaths in the United States in 2002, making it the sixth leading cause of death. However, it is believed that diabetes is generally under-reported on death certificates and as such the toll of diabetes may be much higher than officially reported. Beyond the toll on human life, the total annual economic cost of diabetes in 2002 was estimated to be $132 billion or one out of every 10 health care dollars spent in the United States.
Keywords: Diabetes mellitus, Hyperglycemia, Insulin.
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