EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

HYALURONIDASE INHIBITORY ACTIVITY OF CHONDROITIN SULFATE AND GLUCOSAMINE SULFATE

Man Kyu Huh*

ABSTRACT

The hyaluronic acid, glucosamine, chondroitin are now used as health food by many persons in many countries including Korea. Hyaluronic acid (HA) is an important component of articular cartilage. Hyaluronidases are a family of enzymes that degrade hyaluronic acid. The inhibitory effects of HAase by chondroitin sulfate and glucosamine sulfate were assayed using a Morgan microplate assay. Methanol extract of the chondroitin sulfate was evaluated 36.0% on 800 mg/L and that of the ethanol extract was 35.1% at same concentration. Overall, compounds including glucosamine sulfate and chondroitin sulfate were slightly higher in HAase inhibitory activity than those of pure chondroitin sulfate. Methanol extract of the glucosamine sulfate with chondroitin sulfate was evaluated 41.7% on 800 mg/L and that of the ethanol extract was 40.8% at same concentration. There was significant difference between pure chondroitin sulfate groups and compounds including glucosamine sulfate and chondroitin sulfate groups (p <0.05). The results of this study suggest that the stem extract of chondroitin sulfate has significant HAase inhibitory effect. Chondroitin sulfate and glucosamine sulfate may be useful compounds for studies connected with the hyaluronidase inhibition.

Keywords: Chondroitin sulfate, Glucosamine sulfate, HAase inhibition, Hyaluronidase.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database