SEROLOGICAL STUDY FOR SOME OF IMMUNE FACTORS ON THYROIDITIS PATIENTS

Zainab A. Fadhil*, Abd Alkader A. Mohamed and Lekaa N. Abdulah

ABSTRACT

Abstract. thyroiditis disease is an autoimmune inflammationIt has genetic, clinical, pathological, and immunological features, and it goes through alternating phases of healing and relapse. The aim of this study was to assess the immunological status of some Iraqi Thyroiditis patients. The present study was conducted on a groups of patients. This study was conducted for a period from the beginning of October 2020 to the end of January 2021, as blood samples were collected from patients with thyroiditis, as well as healthy people from Baquba Teaching Hospital and Al-Batoul Hospital Education Feminine & Pediatric in Diyala Governorateaged 27 female and 3 males healthy participants included in this study as a control group. Their ages ranged between (18-45) years. Hyperthyroidism Group 25 female and 5 males patients. Their ages ranged between (23-60) years. Hypothyroidism Group 30 female patients. Their ages ranged between (21- 60) years. The research looked into the relationship between immunological detection of Immunoglobulin A cellular motility and the ELIZA technique. The current study's findings revealed a non-significant decrease in serum IgA level in hypothyroidism group (29.12 ± 2.67) ng/ml and when compared with the control group (42.46 ± 9.89) ng/ml while the result revealed that there were a significant (P< 0.010) increase in serum IgA level in hyperthyroidism group (61.84 ± 16.94)ng/ml. when compared with control group (42.46 ± 9.89) ng/ ml. These findings suggest that Immunoglobulin A might have a role in etiopatho genesis of Thyroiditis disease.

Keywords: Hypothyroidism, Hyperthyroidism, Immunoglobulin A.