METHOD DEVELOPMENT FOR ANALYSIS OF LOSARTAN POTASSIUM IN PHARMACEUTICAL SAMPLES USING TURBIDITY FLOW INJECTION

Abbas l. Azeez, Saba A. Hameed and Firas T. Kareem,*

ABSTRACT

Determination of Losartan Potassium in its pure form and pharmaceutical preparations in a new method, accurate, rapid, sensitive, and low cost. The process was based on the formation of a white precipitate by the reaction of LOS with cadmium chloride in an acidic solution. Use a homemade flow injection technique for precipitate measurement and a continuous flow injection approach. Reagent concentration, acidic medium, flow rate, sample volume, and purge time are chemical and physical parameters that can be improved. The linear dynamic range of the LOS was 0.1-1.5 mmol/L with a linearity ratio (r2%) 93.42%. The lowest concentration of the calibration graph (L.O.D) of 6.3 μg/sample and (LOQ) was 39.1 μg/sample. The developed method and the classical methods were compared. The proposed method is effectively used to determine LOS in pharmaceutical samples and its alternative method.

Keywords: Losartan potassium (LOS), flow injection analysis, Turbidity, cadmium chloride.