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An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57



L.N. Abdulla*, Doaa A. Abdulwahab and Dina A.A Abdullah


This study was designed to investigate the role of pomegranate seed oil as antioxidant in ameliorating the deleterious effects of methionine overload on cardiovascular function of adult female rabbits. Thirty-Two female rabbits were randomly assigned into four equal groups (eight animals in each group) and treated for 42 days daily as follows: The first group were drenched corn oil, serving as control (group C), the second group (group T1) were intubated orally with methionine 100mg/kg. B.W, while thethird groups (groupT2) were intubated orally with methionine 100mg/kg. B.Wand pomegranate seed oil 30 mg /Kg. B.W, while theanimals in the groupT3were intubated orally with pomegranate seed oil 30 mg /Kg. B.W. The electrocardiographs (ECG) were recorded for rabbits in allexperimental groups at the same interval of the experiment, The analysis of ECG in rabbits treated with methionine (T1) showed a significant decrease in p wave, QRS wave and T wave amplitude, also significant increase in QRS and T wave interval as well as significant prolongation in P-Q and Q-T interval. On the other hand, the cardioprotective role of pomegranate seed oil was clarifiedin animals ofgroupT3, but it was less effective in methionine treated rabbits, where the oil fail to restore P, P-Q, Q-T wave in group T2 to normal level. In conclusion, the results of this study clarified the deleterious effect of methionine overload on electrical conduction of the heart represented by abnormality of ECG component, as well as the present study confirms the cardioprotective role of pomegranate seed oil as antioxidant by ameliorating effect of methionine and keeping the normal shape of QRS wave and prevent prolongation of Q-T interval.

Keywords: Pomegranate seed oil, Methionin overload, Antioxidant, oxidativee stress, cardiac muscle.

[Full Text Article]




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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia