BIGEL: A NEW APPROACH IN NOVEL DRUG DELIVERY SYSYTEM
Neha Yadav*, Kavita Vijay, Dr. Mayank Bansal and Manoj Gupta
ABSTRACT
Topical administration is applied to deliver a drug instantaneously at the point of application, so enough drugs is depleted into the systemic circulation to cause medicinal effects. To develop an effective drug absorption through an intact skin, several topical preparations are used one of that is “Gels”. Gels basically used for the purpose of topical dosage form a lot which is to deliver drug across a localized area of the skin. Gel formulation contributes for better approach concept and product stability in respect to ointment, paste and cream. Administration of topical gel drug has a limited drug delivery process anywhere in the body system through skin route, vaginal route, rectal route and ophthalmic route as darmal routes. Generally gels used in wide range as applications in food products, cosmetics products, biotechnology. Most of the gels may be designed according to their nature of the liquid phase, for example, Organic solvent containing are organogels (oleogels) and water as solvent phase called hydrogels. Recent research studies have reported many types of gels for topical drug application, like aerogel, bigel and emulgel. Topical dosage forms like Gels are evaluated with following standard parameters such as pH of formulation, homogeneity of preparation, grittiness of active drug content, extrudability and spreadability of formulation, skin irritation studies, in-vitro release and Stability studies.
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