EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

FORMULATION AND EVALUATION OF POLYHERBAL LOZENGES FOR THE TREATMENT OF ORAL ULCERS

Bariki Rajasekhar*, C. Supriya, K. Guru Lakshmi, M. Shireesha, M. Mujeeb Ur Rehaman, P. Prasanna Kumar and Y. Saroja

ABSTRACT

Herbal Medicines are still the mainstay of about 75-80% of the world’s population, mainly in developing countries. They are found mainly in tropical and subtropical regions of the India for primary health care because of better compatibility with human body, cultural acceptability and lesser side effects. Herbal Formulations are derived from Herbal plant extracts and these are being increasingly utilized to treat a wide variety of diseases. The main objectives of present investigation were to formulate and evaluate polyherbal lozenges for the treatment of oral ulcers by using ethnolic extracts of guava, liquorice, neem, tulasi and different concentration of Hydroxypropyl Methylcellulose, Methylcellulose polymers. The prepared polyherbal lozenges formulations were characterized for various parameters like hardness, thickness, weight variation, friability and dissolution by standard pharmacopeia methods. However, that among all formulations, HF3 Polyherbal Lozenges was proved most promising formulation as it showed that 93.74 % drug release with in 30 minutes. The diameter, thickness and hardness of lozenges were found to be 16.11±0.08mm, 6.552±0.02mm and 5.5 ± 0.3 (kg/cm2) respectively. The percentage of weight variation was found to be 3000.6 ± 2.65 mg. The friability of lozenges was found to be 0.92 ± 0.02 (%). Among all the Formulations HF3 with HPMC Polymer Polyherbal Lozenges showed best results because all the Evaluation parameters showed satisfactory results.

Keywords: Guava, Liquorice Neem, Tulasi, Polyherbal formulation, Lozenges, Ulcer treatment.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia