EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia ,

ISSN 2394-3211

Impact Factor: 7.065

ICV - 79.57

Abstract

EVALUATION OF NEPHROPROTECTIVE ACTIVITY OF CADABA FRUTICOSA LEAVES BY GENTAMICIN INDUCE NEPHROTOXICITY ON EXPERIMENTAL ANIMALS

Firoz Khan*, Dr. Nasiruddin Ahmad Farooqui, Praveen Kumar and Jiyaul Hak

ABSTRACT

The protective effect of Cadaba fruticosa leaves extract against Gentamicin-induced nephron toxicity into Wistar albino rats was examined through several biochemical limitations. Renal damage produced through Gentamicin was well revealed by a substantial improve in renal parameters like volume of urine, body mass, serum creatinine, serum bun, creatinine clearance, MDA Level, SOD, CAT, glutathione proxidise, reduce glutathione, serum uric acid, blood urea nitrogen, and serum urea. Oral administration of Kadaba furticosa levees ethanolic extract (150 mg/kg and 300 mg/kg, p.o) along with Gentamicin restored these altered parameters to normal levels, indicating the protective effect of Kadaba furticosa on Gentamicin-induced renal injury. More extensive research is needed on its potential use in clinical practice.

Keywords: MDA Level, SOD, CAT, glutathione proxidise, reduce glutathione.

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