EVALUVATION OF GASTROPROTECTIVE ACTIVITY OF URARIA PICTA ROOT EXTRACT ON EXPERIMENTAL ANIMALS

Asif Ali*, Prof. Praveen Kumar, Dr. Shamim Ahmad, Dr. Nasiruddin Ahmad Farooqui and Jiyaul Hak

ABSTRACT

In the present study, we examined the gastro protective effect of uraria picta root extract against ethanol-induced gastric mucosal lesions in rats. The gastric mucosal lesions were produced by oral administration with various concentrations of ethanol for three days, and 75% ethanol treatment was determined to be the optimal condition for induction of gastric damage. To identify the protective effect of uraria picta root extract on ethanol-induced gastric damage, various doses of uraria picta root extract were given as pretreatment for three days, and then gastric damage was induced by 75% ethanol treatment. Selenium showed a protective effect against ethanol-induced gastric mucosal lesions in a dose dependent manner. Specifically, 300 mg/kg of uraria picta root extract showed the highest level of gastro protection. In addition, uraria picta root extract markedly attenuated ethanol-induced gastric ulcer index in gastric mucosa, volume of gastric juice, pH of gastric juice, free acidity in gastric juice, total acidity, pepsin content and DNA content. Histological data showed that 300 mg/kg uraria picta root extract distinctly reduced the depth and severity of the ethanol induced gastric lesion. These results clearly demonstrate that uraria picta root extract inhibits the formation of ethanol-induced gastric mucosal lesions.

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