SUCCESSFUL MANAGEMENT OF PCOS WITH A NON-HORMONAL, COMBINATION THERAPY OF AYURVEDIC FORMULATIONS

*Dr. Divya C.S., Dr. Manu K.N. and Dr. Aarti Patil

ABSTRACT

Objective – The objective of the study was to evaluate the efficacy and safety of non-hormonal combination therapy of Ayurveda formulations in females suffering from irregular menstrual cycles due to PCOS. Materials & Method – The study was an open-label, non-comparative, single centre, prospective, interventional clinical study. A total of 190 female patients suffering from PCOS (diagnosed by USG) between the age group of 15-40 years having complaints of irregular menstrual cycles were recruited in the study. Participants were advised to take combination therapy of two proprietary marketed products containing ingredients like Kanchanaar, Shatavari, Dashmool etc. (Myrah and Vamah Tablets) in a dose of 2 tablets twice daily with water for 6 months. Monthly follow up of participants was done to assess frequency of menstrual cycle, no of days of bleeding, quantity of bleeding and associated symptoms while USG was repeated at the end of the study. Results – Female participants of average age 23.05 ± 7.78 having PCOS over a period of 6.78 ± 3.45 months were recruited. A total of 137/190 participants (72.10%) reported of regular menstrual cycles at the end of 6 months. The No. of days of bleeding increased from 1.21 +/- 0.34 at baseline to 2.22 +/- 1.29 at the end of three months and 3.32 +/- 1.59 at the end of 6 months (p<0.05). Similarly quantity of bleeding also showed significant increase over the period of 3 and 6 months. USG was performed in 121 participants of which 45 subjects (37.19%) showed complete resolution, 48 subjects (39.66%) showed partial resolution while 27 participants (22.31%) did not show any change. None of the participants showed worsening in their condition. No adverse drug reaction was observed and the study products were well tolerated. Conclusion- Combination therapy of Ayurvedic tablets (Myrah & Vamah) was found to be effective in regularising menstrual cycles, improving overall menstrual flow and managing PCOS.

Keywords: PCOS, Myrah Tablets, Vamah Tablets.