SERUM CALCIUM AND ALKALINE PHOSPHATASE LEVEL AMONG PRE-MENOPAUSAL AND POST-MENOPAUSAL WOMEN ATTENDING IN SUBHIMALYAN PERIPHERAL INSTITUTES A CO-RELATIONAL STUDY

Priyanka G. and Jyoti S.*

ABSTRACT

The bone turnover markers and their consequences to poor health outcome among the post- menopausal women have well been understood elsewhere, but its not well researched in our part of world. Objective: Aim of this study was to assess the association of the bone turnover markers in pre- vs post- menopausal women attending our peripheral health institutes in sub Himalayan region. Methods: It was a cross-sectional study which was conducted during September 2021 to February 2022 in a total of 200 study participants in our subhimalyan peripheral institutes CH Bhawarna and RH Bilaspur with an equal number of pre- and post-menopausal women (100 each of the test and control group). Blood samples for both the pre-menopausal vs post-menopausal women were collected and then analyzed for selected bone turnover markers. Descriptive statistics correlation statistics were employed for our study. Data were then analyzed using SPSS software. Results: This study identified that the low serum calcium level. (Post-menopausal; mean 8.32, SD vs. pre menopausal; mean 9.32, SD≤2) and high alkaline phosphatase (ALP) level in postmenopausal women compared to that of its counterparts [post-menopausal group 105.5 compared to that of pre-menopausal group 85.50]. There was a negative correlation which was significant between serum calcium and alkaline phosphatase. Conclusion: As the result of this study showed a significant decrease in the serum calcium and increase in the serum ALP among normal postmenopausal women suggesting an elevated bone turnover which may result into bone mass reduction, hormonal therapy to prevent bone mass reduction to concerned population may be suggested. Studies covering bone markers in a larger population size are recommended.

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