FORMULATION AND EVALUATION OF ANTI-DIABETIC POLYHERBAL CAPSULES

Dr. Mamatha Rao, Swathi Vijaya P.* and Vinutha L. and Pallavi B.

ABSTRACT

Diabetes mellitus is a chronic metabolic disorder characterized by imbalance in carbohydrate, protein and lipid metabolism resulting in hyperglycemia this is mainly caused by inadequate insulin secretion or insulin dysfunction.[1] Worldwide there is a drastic increase in Diabetes mellitus patients especially in developed countries. According to International Diabetes Federation (IDF), in 2021, approximately 537 million adults are suffering from this heterogenous metabolic disorder. By 2030, it is estimated to rise by 643 million adults.[2] Diabetes mellitus should be diagnosed and effective treatment should be provided, if not, it can further lead to complications such as Diabetic Retinopathy, Diabetic Neuropathy, Diabetic Nephropathy [Micro vascular complications], Cardiovascular Diseases, Atherosclerosis, Stroke [Macro vascular complications] and many more.[3] Synthetic Antidiabetic formulations shows side effects like Weight gain, Hypersensitivity reactions, Hepatotoxicity, GI disturbances, Lactic acidosis, Vitamin B12 deficiency, Ocular disturbances, Lipoatrophy and many others.[4] Therefore to avoid complications and side effects of synthetic preparations, there is a need for a polyherbal antidiabetic formulation which shows effective and potent action in comparison to synthetic formulations. Hence in the present study, an attempt was made to formulate polyherbal antidiabetic formulation, using Cucurbita maxima, Moringa oleifera, Acalypha indica, Phyllanthus emblica, Nigella sativa, Trigonella foenum-graecum, Murraya koeniggi, Ocimum sanctum, Curcuma longa, Cinnamon cassia, Zingiber officinale in the form of capsules. The prepared formulation was evaluated for Uniformity in weight, Bulk density, Tapped density, Angle of repose, Hausner’s ratio, Carr’s index, Stability test, Moisture content, Disintegration test, Dissolution test and was found to be satisfactory.

Keywords: Anti diabetic, Polyherbal, Cucurbitamaxima, Moringaoleifera, capsules.