DESIGN AND DEVELOPMENT OF INVITRO CHARACTERIZATION OF FLOATING MICROSPHERES OF RANOLAZINE
V. T. Iswariya*, G. L. Soujanya, R. Santhosh, A. Pradeep Kumar, J. Lingaswamy, K. Satyanarayana
Ranolazine (RZ) is an antianginal agent employed in therapy of cardiovascular diseases such as myocardial infarction, variant and exercise-induced angina and arrhythmias constipation, headache, nausea and dizziness are the most common side effects. So the aim of the present research work was to formulation and in vitro evaluation of ranolazine microspheres using Sodium alginate along with Carbopol 934, Carbopol 971, HPMC K4M as copolymers The results of this work indicate that ionic cross linking technique Ionotropic gelation method can be successfully employed to fabricate Ranolazine microspheres.Increase in the polymer concentration led to increase in % Yield, % Drug entrapment efficiency, Particle size, % swelling and % Mucoadhesion. The in-vitro mucoadhesive study demonstrated that microspheres of Ranolazine using sodium alginate along with Carbopol934 as copolymer adhered to the mucus to a greater extent The invitro drug release decreased with increase in the polymer and copolymer concentration. FT-IR spectra of the physical mixture revealed that the drug is compatible with the polymers and copolymers used.
Keywords: Ranolazine, Carbopol, Microspheres.
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