EVALUATION OF RISK FACTORS ASSOCIATED WITH GASTRIC CARCINOMA

Dr. Md. Shariful Islam*, Dr. Bimal Chandra Roy, Dr. Md. Abdul Baset, Dr. Bhupal Chandra Barman, Dr. Md. Hamidul Islam, Dr. Md. Abdul Jabbar and Dr. A.K.M. Kamrul Huda

ABSTRACT

Background: Worldwide, gastric carcinoma is one of the leading causes of death. In some Asian countries, it is still the commonest cause of cancer death in patients for last 50 years. Gastric Carcinoma is a multi-factorial disease resulting from an interplay between host genetic susceptibility and Environmental risk factors. Objective: To evaluate the Risk Factors Associated with Gastric Carcinoma. Methods: This cross-sectional descriptive study was conducted at inpatient department of Surgery of Rangpur Medical College Hospital. After taking permission a total 40 eligible patients aged above 18 years who met the inclusion criteria were enrolled into this study. Proper history taking and meticulous physical examination was done. Endoscopy of upper gastrointestinal tract (GIT), then histopathological examination of biopsied gastric tissue sample and antibody to H.pylori was done. Data was analyzed through SPSS (Statistical Package for Social Science) software version 21.0. Significance for the statistical tests (Chi-Square test, z-test) were predetermined at a probability value of less than 0.05 (p<0.05). Quality was assured through avoidance of missed data, filling of code, regular entry of data and careful data analysis. Ethical considerations met through achieving an informed written consent after briefing objectives. Result: Among 40 respondent smoking, duration of smoking, amount of smoking and Helicobacter pylori (antibody) were found statistically significant with gastric carcinoma. It was found that smoker were 67.5% (n=27) and non-smoker were 32.5% (n-13) and smoking was statistically significant (p<0.01) with Gastric Carcinoma. The number of smoker according to their duration of smoking were <5 years 3.7% (n=01), 5-10 years 3.7% (n=01) and >10 years 92.6% (n=25), the duration of smoking was statistically significant (p<0.001) with gastric cancer. This current study also found that >20 cigarettes stick taker per day were 48% (n=13), 10-20 cigarettes stick taker per day were 44% (n=12) and <10 cigarette sticks taker per day were 8% (n=02), the amount of cigarette sticks taken per day was statistically significant (p<0.001) with Gastric Carcinoma also. This study also found that, among the respondent Helicobacter pylori (antibody) positive 72.S% (n=29) and negative 27.5% (n=11) and H. pylori was statistically significant (p<0. 001) with Gastric Carcinoma. Conclusion: The study findings will help to evaluate the risk factors of gastric carcinoma.

Keywords: Gastric carcinoma, Prevention and Risk factors.