EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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ISSN 2394-3211

Impact Factor: 7.065

ICV - 79.57

Abstract

STUDY OF FAS AND FAS LIGAND RESPONSE DURING TOXOPLASMOSIS INFECTION FOR ABORTED WOMEN

Reem A. Mansour*, Dina A.A Abdullah and Doaa A. Abdulwahab

ABSTRACT

Background: The current study was conducted in Diyala governorate during the period from 10 October 2020 to February 2021 to investigate the levels of some immune variables among aborted women with Toxoplasma gondii infection by used ELISA test to detect IgM and IgG antibodies, also to evaluate the concentration of Fas and Fas-ligand in aborted women as well as to investigate the relation between Toxoplasma gondii infection and (Fas and Fas-ligand) and how they effects during the infection with Toxoplasma gondi. Methodology: One hundred twenty women were included in this study that suffering from previous abortion with close ages and apparently 03 healthy women were considered as a control group. All patients who shared in current study were attending Al-Batoul Maternity Teaching Hospital in Baquba city- Diyala governorate in the period from October 2020 to February 2021. Their ages ranged between (15 - 50) years. Results: This study showed that 60 women were positive by ELISA (IgG and IgM) which considered as confirmed toxoplasmosis cases, 19 (31.7%) of abortive women had IgM+, 32 (53.3%) had IgG+, and 9 (15.0%) had both IgM+ and IgG+, whereas the control women were 0% for all types of antibodies. The highest results of serological tests were observed in women of age group (25-34) years (30%). Also there was a relationship between the increasing in the seropositive of aborted women for anti-T. gondii in women who have single abortion 34 (56.7%), and women from rural areas 35 (58.3%). The present study observed that there was an increase of serum level of Fas and Fas-ligand among women with toxoplasmosis who have positive IgM and positive IgG or both positive IgM and positive IgG. Conclusion: There is an association between infection with T. gondii and occurrence of abortion and the age group (26-35) years was the most affected among the other age groups and the most likely to have abortion as well as Toxoplasma gondii has role in change of FAS, FAS-L.

Keywords: Toxoplasma gondii, pregnant women, fas, fas-ligand, ELISA test.

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