EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

DEVELOPMENT OF NANOSPONGES BASED ON VORICONAZOLE LOADED ?-CYCLODEXTRIN

Shubhanshi Chaudhary*, Pushpendra Jain, Jiyaul Hak, Tridev Singh Rajput

ABSTRACT

Aim: To formulate and evaluate of voriconazole loaded β-cyclodextrin based nanosponges. Methodolgy: The ratios of ethyl cellulose to polyvinyl alcohol vary while making these nano-sponges. Polyvinyl alcohol (0.2 percent w/v) was dissolved in dichloromethane (20 ml) and slowly added to 150 ml of aqueous continuous phase with the ethyl cellulose and drug-containing dispersion phase. It was agitated for two hours at 1000 rpm. Filtration was used to collect the nanosponges, which were then dried for 24 hours at 400 degrees Celsius in an oven. A vacuum desiccator was used to remove any remaining solvent from the dried nanosponges. It was discovered and analysed which factors in the formulation have an impact on the manufacture and qualities of nanosponges. Polymer (β-Cyclodextrin, PVA) and cross-linker ratio (Dichloromethane), Stirring speed and time are examples of process variables. The particle size and polydispersity index were used as the foundation for the optimization. Results: The voriconazole entrapped nanosponge drug entrapment effectiveness in all of its produced formulations. All nanosponge formulations had drug entrapment effectiveness ranging from 81.66 percent to 93.11 percent, with the F4 formulation having the highest, at 93.11 percent. Conclusion: Voriconazole nanosponge release tests were conducted in a pH 1.2 buffer diffusion medium for 12 hours. It had a biphasic release with a burst effect at the beginning. F1 to F6 had a total of 19.6 mg of medication released in the first 30 minutes.

Keywords: Voriconazole nanosponge, ?-cyclodextrin, Stability, Antifungal.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database