EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia ,

ISSN 2394-3211

Impact Factor: 7.065

ICV - 79.57

Abstract

STABILITY STUDY OF DIFFERENT MARKETED BRANDS OF DICLOFENAC SODIUM AND PARACETAMOL TABLETS BY USING SPECTROPHOTOMETRIC METHOD

Anjan Shankar Ladage*, Umesh Rangat, Bharatee Chaudhari and Vivekkumar Redasani

ABSTRACT

The forced degradation study of different marketed formulation of combined tablets of Paracetamol and Diclofenac was performed. Paracetamol and Diclofenac was exposed to different conditions according to International Conference on Harmonization guideline. The amount of degradation product can be calculated with the help of UV spectrophotometer. The official test limits according to Indian Pharmacopoeia/United States Pharmacopoeia were considered. The marketed brands of Diclofenac Sodium and Paracetamol are Deemol-500,DIK-MR,Oxan Plus used in study as this method is less time consuming and simple and cost effective. The brands Deemol-500, DIK-MR, Oxan Plus when come in contact with different degradation parameters acid, base, and UV treatments they show negligible effects.

Keywords: UV Spectroscopy, Paracetamol and Diclofenac Sodium, UV Cabinet, Degradation.

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