STABILITY STUDY OF DIFFERENT MARKETED BRANDS OF DICLOFENAC SODIUM AND PARACETAMOL TABLETS BY USING SPECTROPHOTOMETRIC METHOD

Anjan Shankar Ladage*, Umesh Rangat, Bharatee Chaudhari and Vivekkumar Redasani

ABSTRACT

The forced degradation study of different marketed formulation of combined tablets of Paracetamol and Diclofenac was performed. Paracetamol and Diclofenac was exposed to different conditions according to International Conference on Harmonization guideline. The amount of degradation product can be calculated with the help of UV spectrophotometer. The official test limits according to Indian Pharmacopoeia/United States Pharmacopoeia were considered. The marketed brands of Diclofenac Sodium and Paracetamol are Deemol-500,DIK-MR,Oxan Plus used in study as this method is less time consuming and simple and cost effective. The brands Deemol-500, DIK-MR, Oxan Plus when come in contact with different degradation parameters acid, base, and UV treatments they show negligible effects.

Keywords: UV Spectroscopy, Paracetamol and Diclofenac Sodium, UV Cabinet, Degradation.