EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

PREPARATION AND EVALUATION OF IN SITU GEL CONTAINING ACYCLOVIR

*Sreenimya M.P. and Sujith S. Nair

ABSTRACT

In situ gel dosage forms were successfully used as drug delivery systems to prolong the residence time and to reduce the frequency and amount of administration. The main objective was to prepare and evaluate oral mucoadhesive in situ gel containing acyclovir based on the concept of pH triggered system. The system utilizes polymers that exhibit sol to gel phase transition due to change in specific physico-chemical parameters. A pH triggered system consisting of carbopol 934P along with hydroxypropylmethylcellulose was used to prolong the release of acyclovir, Formulations were evaluated for sol-gel temperature, gelling capacity, pH, viscosity, spreadability, gel strength Mucoadhesive force, drug content and in vitro release. The use of carbopol as in situ gel forming system was sustained by the property to transform into stiff gels when the pH was raised. The viscosity was found to be in the range 82-199 centipoise for the sol, where for the gel was up to 1594 centipoise. The maximum gel Strength and mucoadhesion was found to be up to 50.8dynes/cdynes/c2 and 6219 dynes/cm2 respectively. The optimized formulations were able to release the drug up to 97.2%. In situ gel formulation of Acyclovir with mucoadhesive properties was found to be promising for prolonging buccal residence time and thereby better therapeutic effects.

Keywords: Acyclovir, In Situ Gel, Mucoadhesive, Carbopol, HPMC.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database