EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

COMPARATIVE STUDY OF SERUM CRP LEVELS VS APACHE –II SCORING SYSTEM IN DETERMINING SYSTEM THE SEVERITY OF ACUTE PANCREATITIS

Malik Shahnaz, Snober Malik, Amat us Sami*, Sheeba Altaf, Naveed Bashir

ABSTRACT

Background: Acute pancreatitis (AP) is a common digestive disease and the most frequent disorder of the pancreas. In third world settings, a simple scoring system predicting severity and outcome can help in improving outcome of these patient. In this regard a study was conducted to determine whether APACHE or CRP will help in developing a better scoring system for predicting outcome and severity. Results: On comparing serum CRP level > 150 mg/L with an APACHE II score of > 8, to predict a severe attack, it was seen that the former had a higher sensitivity, negative predictive value and overall accuracy compared to the latter. Again it was seen that APACHE II score had a higher specificity and positive predictive value as compared to serum CRP. However these differences were marginal, with an overall almost similar accuracy (CRP – 82 %; APACHE II – 80 %), but serum CRP scores over APACHE II in being less cumbersome, less complicated and highly cost effective. Conclusion: Since improved outcome in the severe form of AP is based on early identification of disease severity and subsequent focused management of these high-risk patients, we advocate the use of serum CRP as a routine test in patients of acute pancreatitis, to predict a severe attack of acute pancreatitis early in the course of disease and thus decrease overall mortality and burden of disease.

Keywords: .


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia