EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

PROGNOSTIC MARKERS FOR ACUTE VARICEAL BLEED IN PATIENTS WITH CIRRHOSIS OF LIVER AND PORTAL HYPERTENSION

Anoop K. Koshy*, Bilal Mohmed, Harshavardhan B. Rao, Priya Nair and Krishna Priya

ABSTRACT

Background and Aims: Variceal bleed is the most lethal complication of liver cirrhosis. Several factors and scoring systems have been known to predict the outcome of variceal bleed. The aim of the study was to assess the efficacy of current known factors and prognostic scoring systems in predicting short term outcome in patients presenting with variceal bleeding. Materials and Methods: The study was a prospective observational study that included 127 adult patients with cirrhosis and portal hypertension who presented with variceal bleeding. The outcomes measured were mortality and length of hospital stay ( 7 days). A poor outcome was taken as mortality or hospital stay > 7 days. Categorical variables were expressed using frequency and percentage. Numerical variables were presented using mean and standard deviation. Chi-square test with continuity correction was used to study the statistical significance of the association of all categorical variables with the outcomes mortality and hospital stay. Student’s t test was used to study the statistical significance of the comparison of all continuous demographic and clinical parameters between outcomes. Results and Conclusion: The study showed that total counts, platelet counts, INR did not have significant association with poor outcomes. Presence of hepatic encephalopathy, renal failure and a MELD score >/= 14 were found to have association with mortality in variceal bleed. CHILD C status, presence of hepatic encephalopathy, MELD score >/= 14, AIMS 65 score of >/=2 and Glasgow Blatchford Score (GB score) >8 were predictors of a prolonged hospital stay.

Keywords: Cirrhosis, variceal bleed, prognostic markers.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database