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An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57



Isesele Ejededawe Jude, Airemwen Collins Ovenseri*, Uchendu Phina Adaeze, Asemwota Iwinosa Osamudiamen, Johnbull Aiwaguore Obarisiagbon and Uhumwangho MU


The aim of this study was to formulate ibuprofen loaded implants using some biodegradable polymers and to evaluate the analgesic effect in vivo using mice. Solvent casting technique was employed for the formulation of ibuprofen loaded implant pellets using gelatin-sodium alginate admixture (80:20) as the polymer blend. Glycerin was used as the plasticizing agent. The cut pellets were evaluated for their physicochemical properties such as weight uniformity, thickness, swelling index, moisture content, moisture sorption, drug content, drug-excipient interactions as well as in vitro drug release. The in vivo analgesic activity of the implants on acetic acid-induced mouse writhing in mice was also determined. The implant pellets had uniform character with minimum batch to batch variation. The mean diameter/thickness of the implants ranged from 2.91 ± 0.02 - 3.05 ± 0.01 mm, mean weight variation was 123 ± 0.1 to 128 ± 0.1 mg, mean percentage drug content was between 96.75 ± 0.11- 98.25±0.12%, mean percentage moisture content ranged from 26.12 ± 0.03 – 31.50 ± 0.01% and swelling index values were between 4.50 ± 0.01 - 5.24 ± 0.02%. In vivo analgesic activity of the ibuprofen implants significantly inhibited acetic acid-induced writhing in mice as compared to the control. Ibuprofen biodegradable implants which can be used in the management of chronic disease such as arthritis was successfully formulated using the solvent casting technique.

Keywords: Ibuprofen, implants, biodegradable, sodium alginate.

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  • New Issue Published

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia