FORMULATION AND EVALUATION STUDIES OF DANTROLENE SODIUM AND DICLOFENAC SODIUM GEL TOPICAL GELS FOR TEMPOROMANDIBULAR JOINT SYNDROME

*Subham Tiwari, Harish Pandey and Sunil Kumar Shah

ABSTRACT

ABSTRACT The present study describes a study on “Formulation and Evaluation studies of Dantrolene sodium and Diclofenac sodium gel topical gels for Temporomandibular joint syndrome” Different formulations of dantrolene sodium and diclofenac sodium were prepared by using Carbopol-934, Carbopol-940, Hydroxypropyl methyl cellulose and Sodium carboxy methyl cellulose in varying proportions. Carbopol gels were transparent, non-greasy and smooth on application. Sodium CMC and HPMC gels were opaque, non-greasy and sticking on application. The gel was prepared using 1% Carbopol-934 has maximum drug content (101.72%) than the others. The pH of the formulations ranged from 6.8 to 7.2 and viscosity is from 36,000 to 51,000cps. Extrudability of carbopol and HPMC gels were excellent than the Sodium CMC gel. The spreadability data shown that the formulation with 1% Carbopol- 934 has the highest value (8cm), where as the others have significant values. In vitro release studies of the formulations were carried out across the cellophane membrane using a diffusion cell. From this investigation, it was concluded that formulation A2 with 1% Carbopol-934 may be the best formulation having good in vitro release profile, stability. Based on the results from the study further utility of the dosage form may depend on pharmacokinetic data. Forthcoming research work of musclerelaxant activity of dantrolene sodium may contribute in the challenging area.

Keywords: Musclerelaxant, Temporomandibular joint, Transdermal drug delivery systems, Dantrolene sodium, Diclofenac sodium.