DESIGN, SYNTHESIS AND EVALUATION OF ANTIMICROBIAL AND ANTICANCER ACTIVITY OF NOVEL 3-AMINOMETHYL PYRIDIN DERIVATIVES

Nirav Shah and Shubhangi Soman*

ABSTRACT

In search of new nitrogen, oxygen and sulphur containing heterocyclic compounds with improved antimicrobial, antifungal and anticancer activities, we report herein the synthesis of amide derivatives 2a-g and 5a-f obtained by reaction of 3-aminomethyl pyridine with phenyl bromo acetamide 1a-f and (N-substituted benz [d]thiazol-2-yl) 2-bromo acetamide 4a-g derivatives respectively. All the synthesized compounds were evaluated for their antimicrobial and anticancer activities. Compound 2a and 2b showed IC50 values 0.2129 μM and 1.186 μM respectively against A549 lungs cancer cell line, while compounds 2c, 2d and 5a showed promising anticancer activity with IC50 values 0.51μM, 0.14 μM and 0.73 μM respectively against MOLT3 leukaemia cancer cell lines.

Keywords: Aminomethyl pyridine, benzothiazole, antimicrobial activity, anticancer activity.