EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL GUANINE ANALOGUES

Santhosha S. Poojary, Devaraju Kesagodu*, Ranjini P., Rekha N. D., Dhondiba Vishwanath, Chaitra Mallu M. and Basavaraju Y. B.

ABSTRACT

The novel substituted and potent guanines were synthesized in high yields. Guanine analogues especially acyclovir and valaciclovir for the treatment of herpes virus infections, have dominated the antiviral therapy for several decades. Valaciclovir is the L-valyl ester prodrug of acyclovir. It is used in the treatment of Herpes simplex virus and Vericella zoster virus. Herpes virus infections, especially those caused by HSV-1 and HSV-2 are the most common viral infections. In the present work, a series of novel substituted benzyl derivatives of Valacyclovir were efficiently synthesized and the structure of the compounds was confirmed by analytical spectral data. The synthesized new compounds were evaluated for their antibacterial, antifungal and antioxidant activities. Analogues synthesized in the present work exhibits strong to moderate activity. The antibacterial activity was compared with control, (gentamycin, fluconazole, and valaciclovir) 6e and 6f showed antibacterial, compound 6a and 6d showed antifungal acivity. The activity of the synthetic compounds is not significant when compared to the reference compounds gentamycin and flucanozole.

Keywords: Acyclovir, Valacyclovir, HSV-1, HSV-2, Vericella zoster.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia